Hyperlipidemia is defined as an elevation of one or more of the plasma lipids, including cholesterol, cholesterol esters, triglycerides and phospholipids. Hyperlipidemia is the greatest risk factor of coronary heart disease. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidemia has no side effects and is relatively cheap and locally available. Benzoic acid derivative like Protocatechuic acid (PCA), which is predominantly present in the Hibiscus species of plant, possess hypolipidemic, antihyperlipidemic and free radical scavenging activity. In the present study different doses of Protocatechuic acid were evaluated against triton x-100 induced hyperlipidemia in rats. In which various lipid parameters such as, total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) levels in serum were measured and then atherogenic index (AI) was calculated. Protocatechuic acid showed significant decrease (p< 0.01) in the levels of serum TC, TG, LDL, AI levels and significant increase (p< 0.01) in the levels of serum HDL at the dose of PCA (50 mg/kg) against triton induced hyperlipidemia in rats.
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